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Collaboration Without Barriers. Discovery Without Delay.
Manifold’s Trusted Research Environment (TRE) applies AI to simplify secure collaboration and accelerate scientific discovery
Explore Manifold's core solutions
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Unify Every Part of the Research Collaboration Journey
Manifold’s TRE brings together the people, data, and tools that drive modern scientific discovery. Whether you're sharing commercial datasets, collaborating across institutions, or supporting population-scale research, Manifold removes the friction that slows progress while keeping sensitive data fully protected.
Commercial Data Delivery
License and share high-value datasets without losing control. CROs, diagnostics companies, and data aggregators provide governed, access-based environments where partners explore and analyze data securely — without copying, exporting, or exposing raw assets.
Cross-Institutional Collaboration
Work seamlessly with external researchers — without moving sensitive data. AMCs and research institutions grant collaborators secure access to patient cohorts, compute resources, and analysis tools, while your IP remains protected.
Population-Scale Biobanking
Harmonize multi-modal datasets across sites to accelerate precision medicine. Research consortia and national biobank programs unify genomic, clinical, imaging, and biomarker data with consistent governance, reproducibility, and scalable computational infrastructure.
Work Faster, With Confidence
Research Commons eliminates the manual effort historically required to discover data, prepare it, assemble compliant infrastructure, and share it responsibly. By combining AI-driven search, governed access, and integrated analytical tooling—purpose-built for human subjects research rather than generic vendor frameworks—researchers move from idea to insight in a fraction of the time.
AI Cohort Creation
Empower researchers to find data without knowing every table or schema. AI agents help form queries, interpret feasibility results, and highlight relevant attributes — reducing dependency on data stewards and honest brokers.
AI Data Exploration
Onboard to unfamiliar datasets in minutes. Our AI agent answers feasibility questions like “Was this measured?” and “Can I study this here?” while running quick exploratory analyses—histograms, simple comparisons, oncoplots —so you get started faster.
AI Assisted Ingest
Reduce the burden on IT and data owners. Upload new datasets, apply transformations, and run quality checks through intuitive, self-service tools. AI-assisted documentation makes research-ready data appear faster than ever.
Collaborative Spaces
Bring people, data, and tools together in one secure workspace. Researchers, internal teams, and external collaborators can analyze shared data using preconfigured tools — without ever downloading raw data.
End-to-End Data Lineage
See how data was created, transformed, and used — at every step. Research Commons automatically captures lineage, transformations, and usage, allowing teams to trust their results and reproduce them easily.
Governed Access
Protect sensitive data while enabling productive research. Granular permissions, audit trails, differential access paths, and export controls ensure data use aligns with IRB, regulatory, and institutional requirements.
Solutions
Fit-for-purpose solutions for clinical research leaders in cancer and rare disease.
Cancer Observational Study
Streamline legacy systems and manual processes with a single study and data management platform.
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Cancer Center Biobank
Reduce and turnaround time and increase productivity by connecting biospecimen data and clinical data in a single data management platform.
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Cancer Center Registry
Unify clinical and multimodal data on a modern platform to enable automated data preparation into a research-ready patient model.
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Rare Disease Registry
Answer research questions about diagnoses, treatments, and outcomes quickly and easily.
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